In the Amazon the whole is more than the sum of the parts and a regional conservation is need to face the threats and drivers. This an inovative approach of the protected areas system of the region to complement national biological and cultural conservation strategies, thanks to the implementation of the Work Plan for Protected Areas of the Convention on Biological Diversity (CBD), which contributes to maintaining an Amazon that is whole, functional and resilient in the face of climatve change. This initiative shows how multiscale approach and effective partnerhips are essential to protect one of the most important regions in the planet. During the last three years, the Latin American Network for Technical Cooperation for National Parks, Other Protected Areas and Wild Flora and Fauna (REDPARQUES), has led this initiative, with the support and participation from the administration, commissions and members of IUCN, as well as from donors and other organizations. This process was recognized at the CBD COP 10 in Nagoya with the support of the Ministers of the Environment of the Amazon Countries, the international community, along with regional and international NGOs. This is an example of an effective implementation of a resolution approved at the last WCC in Barcelona.